Affiliation:
1. Department of Physiology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Mailstop 634, Greenville, NC 27834-4354, USA
Abstract
Pelvic floor disorders (PFDs) will affect most women during their lifetime. Sequelae such as pelvic organ prolapse, stress urinary incontinence, chronic pain and dyspareunia significantly impact overall quality of life. Interventions to manage or eliminate symptoms from PFDs aim to restore support of the pelvic floor. Pessaries have been used to mechanically counteract PFDs for thousands of years, but do not offer a cure. By contrast, surgically implanted grafts or mesh offer patients a more permanent resolution but have been in wide use within the pelvis for less than 30 years. In this perspective review, we provide an overview of the main theories underpinning PFD pathogenesis and the animal models used to investigate it. We highlight the clinical outcomes of mesh and grafts before exploring studies performed to elucidate tissue level effects and bioengineering considerations. Considering recent turmoil surrounding transvaginal mesh, the role of pessaries, an impermanent method, is examined as a means to address patients with PFDs.
Subject
Biomedical Engineering,Biomaterials,Biochemistry,Bioengineering,Biophysics,Biotechnology
Reference220 articles.
1. PELVIC ORGAN PROLAPSE: FOUR THOUSAND YEARS OF TREATMENT
2. Lifetime Risk of Stress Urinary Incontinence or Pelvic Organ Prolapse Surgery
3. Mid-urethral sling operations for stress urinary incontinence in women;Ford AA;Cochrane Database Syst. Rev.,2017
4. Pessaries (mechanical devices) for pelvic organ prolapse in women. Cochrane Incontinence Group, editor;Bugge C;Cochrane Database Syst. Rev.,2013
5. The Functional Anatomy of the Female Pelvic Floor and Stress Continence Control System
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