Affiliation:
1. Department of Biochemistry, Imperial College of Science,Technology and Medicine, London SW7 2Z, UK
Abstract
Mammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non–living mucosal vaccines and immunostimulators.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
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