Will admixture mapping work to find disease genes?-Reference-Cited by-同舟云学术

Will admixture mapping work to find disease genes?

Published:2005-07-25 Issue:1460 Volume:360 Page:1605-1607
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Reich David¹²,Patterson Nick¹²

Affiliation:

1. Department of Genetics, Harvard Medical SchoolBoston, MA, USA

2. The Broad Institute of Harvard and MITCambridge, MA, USA

Abstract

Admixture mapping is the first experimentally practical method for carrying out a whole-genome association scan, and is thus a promising method for detecting risk factors for common disease. The goal of the community should now be to aggressively test whether the method is useful in practice for localizing disease genes, by carrying out at least three high-powered studies. We also propose a stringent criteria we believe the community should adopt before declaring a statistically significant admixture association to disease.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2005.1691

Reference7 articles.

1. Measuring and using admixture to study the genetics of complex diseases

2. Design and Analysis of Admixture Mapping Studies

3. Prospects for Admixture Mapping of Complex Traits

4. Statistical Tests for Admixture Mapping with Case-Control and Cases-Only Data

5. Methods for High-Density Admixture Mapping of Disease Genes

Cited by 74 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Temporal changes in genetic admixture are linked to heterozygosity and health diagnoses in humans;2019-07-11

2. Inference on admixture fractions in a mechanistic model of recurrent admixture;Theoretical Population Biology;2018-07

3. Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions;Heredity;2017-02-15

4. Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions;2016-10-22

5. Admixture Mapping of African–American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes;Frontiers in Genetics;2016-09-21