Neurodegenerative disease of the brain: a survey of interdisciplinary approaches

Author:

Davenport Franca1,Gallacher John2,Kourtzi Zoe3ORCID,Koychev Ivan45,Matthews Paul M.6,Oxtoby Neil P.7,Parkes Laura M.89,Priesemann Viola10,Rowe James B.11,Smye Stephen W.12ORCID,Zetterberg Henrik1314151617

Affiliation:

1. Freelance writer and King’s College London, London, UK

2. Director of Dementias Platform, Department of Psychiatry, University of Oxford, Oxford, UK

3. Professor of Cognitive Computational Neuroscience, Department of Psychology, University of Cambridge, UK

4. Senior Clinical Researcher, Department of Psychiatry, University of Oxford, Oxford, UK

5. Consultant Neuropsychiatrist, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

6. Department of Brain Sciences and UK Dementia Research Institute Centre, Imperial College London, Oxford, UK

7. UCL Centre for Medical Image Computing and Department of Computer Science, University College London, Gower Street, London, UK

8. School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK

9. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, UK

10. Max Planck Group Leader and Fellow of the Schiemann Kolleg, Max Planck Institute for Dynamics and Self-Organization and Bernstein Center for Computational Neuroscience, Göttingen, Germany

11. Department of Clinical Neurosciences, MRC Cognition and Brain Sciences Unit and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK

12. School of Medicine, University of Leeds, Leeds, UK

13. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK

14. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden

15. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden

16. UK Dementia Research Institute at UCL, London, UK

17. Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, People's Republic of China

Abstract

Neurodegenerative diseases of the brain pose a major and increasing global health challenge, with only limited progress made in developing effective therapies over the last decade. Interdisciplinary research is improving understanding of these diseases and this article reviews such approaches, with particular emphasis on tools and techniques drawn from physics, chemistry, artificial intelligence and psychology.

Funder

NIHR Cambridge Biomedical Research Centre

UK Research and Innovation

Rosetrees Trust

Wellcome Trust

University of Oxford

Medical Research Council

Publisher

The Royal Society

Subject

Biomedical Engineering,Biochemistry,Biomaterials,Bioengineering,Biophysics,Biotechnology

Reference107 articles.

1. Alzheimer's Research UK. 2020 Delivering the Dementia Moonshot. https://www.alzheimersresearchuk.org/wp-content/uploads/2020/01/Delivering-the-Dementia-Moonshot-FINAL.pdf.

2. HM Government. 2021 Life Sciences Vision—Build Back Better: our plan for growth 2021. See https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1013597/life-sciences-vision-2021.pdf

3. Visualisation and quantification of rates of atrophy in Alzheimer's disease

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