Abstract
The cat’s spleen perfused with homologous blood containing prostaglandin E
1
provides an admirable preparation for the study of the liberation and uptake of the sympathetic transmitter. Obstruction of the circulation with platelet thrombi is eliminated; blood flow is high, and overflow of transmitter when the nerves are stimulated is higher than in other preparations. The high overflow of transmitter is attributed to adequate perfusion of a large mass of splenic tissue. There is no evidence that the amount of transmitter liberated per unit mass of tissue is increased. Uptake of liberated transmitter and of infused L-noradrenaline is no different from that observed in other preparations of the spleen.
Reference12 articles.
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