Photopic action of thyrotropin-releasing hormone in the cat retina

Author:

Abstract

The effects of iontophoretically applied thyrotropin-releasing hormone (TRH) on cat retinal brisk-sustained (X) and brisk-transient (Y) ganglion cells were studied in the intact eye in vivo . Under photopic illumination we found a differential action of TRH on ON- and OFF-centre cells: the maintained activity and light response were suppressed in ON-centre cells and enhanced in OFF-centre cells. This was true for both brisk sustained (X) and brisk-transient (Y) cells. In contrast, TRH did not influence the ganglion cell discharge under scotopic stimulus conditions. These results indicate that TRH acts on neurons presynaptic to ganglion cells and these neurons are only active under photopic conditions. We suggest that a possible functional role of this specific action of TRH is in light adaptation.

Publisher

The Royal Society

Subject

General Medicine

Reference21 articles.

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4. Pharmacological modulation of on and off ganglion cells in the cat retina

5. Brecha N. C. 1983 Retinal neurotransmitters: histochemical and biochemical studies. In Chemical neuroanatomy (ed. P. C. Emson) pp. 85-129. New York: Raven Press.

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