Abstract
Intracellular calcium was monitored by the use of aequorin in voltage-clamped oocytes of
Xenopus laevis
. Injection of inositol trisphosphate (IP
3
) into oocytes elicited slowly rising and decaying aequorin/calcium signals and produced oscillatory chloride membrane currents. These responses did not depend upon extracellular calcium, since they could be elicited in calcium-free solution and after addition of cobalt or lanthanum to block calcium channels in the surface membrane. We conclude that IP
3
causes the release of calcium from intracellular stores in the oocyte. Injections of calcium gave aequorin and membrane current responses that were more transient than those seen with IP
3
.
Cited by
130 articles.
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