Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart-Reference-Cited by-同舟云学术

Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart

Published:2009-06-13 Issue:1896 Volume:367 Page:2311-2331
ISSN:1364-503X
Container-title:Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. A.

Author:

Lee Jack¹,Niederer Steven¹,Nordsletten David¹,Le Grice Ian²,Smail Bruce²,Kay David¹,Smith Nicolas¹

Affiliation:

1. Oxford University Computing Laboratory, University of OxfordWolfson Building, Parks Road, Oxford OX1 3QD, UK

2. Bioengineering Institute, University of AucklandAuckland 1142, New Zealand

Abstract

In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation–contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss the importance of model parametrization, imaging-based model anatomy and computational implementation.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsta.2008.0311

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