Towards a Grid infrastructure to support integrative approaches to biological research-Reference-Cited by-同舟云学术

Towards a Grid infrastructure to support integrative approaches to biological research

Published:2005-07-18 Issue:1833 Volume:363 Page:1829-1841
ISSN:1364-503X
Container-title:Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. A.

Author:

Gavaghan D.J¹,Simpson A.C¹,Lloyd S¹,Mac Randal D.F²,Boyd D.R.S¹

Affiliation:

1. Oxford University Computing LaboratoryWolfson Building, Parks Road, Oxford OX1 3QD, UK

2. CCLRC Rutherford Appleton LaboratoryChilton, Didcot, Oxfordshire OX11 0QX, UK

Abstract

This paper discusses the scientific rationale behind the e-Science project, Integrative Biology , which is developing mathematical modelling tools, HPC-enabled simulations and an underpinning Grid infrastructure to provide an integrative approach to the modelling of complex biological systems. The project is focusing on two key applications to validate the approach: the modelling of heart disease and cancer, which together are responsible for over 60% of deaths in the United Kingdom. This paper provides an overview of the project, describes the initial prototype architecture and discusses the long-term scientific aims.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsta.2005.1610

Reference16 articles.

1. eDiamond: A Grid-Enabled Federated Database of Annotated Mammograms

2. RealityGrid: high performance computing, visualisation, computational steering and teragrids;Harting J;Capab. Comput. Newsl. HPCx Commun,2003

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