Affiliation:
1. Department of Health Care Policy, Harvard Medical School180 Longwood Avenue, Boston, MA 02115-5899, USA
Abstract
A precision profile, the relationship between the concentration of a substance and its measured precision, is a convenient way of conveying the ability of an immunoassay to accurately measure the concentration of a substance in blood serum. A precision profile is characterized by the definition of precision. Historically, precision has been evaluated as the standard error of an estimator of the concentration in a sample conditional on the true concentration. In this paper, Bayesian predictive inference is used to develop a new measure of precision based on the accuracy with which an assay could infer the concentration in a hypothetical new sample. This leads to a natural procedure for evaluating a precision profile that avoids using approximations such as those inherent in traditional methods.
Subject
General Physics and Astronomy,General Engineering,General Mathematics
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. BPA Endocrine Disruptor Detection at the Cutting Edge: FPIA and ELISA Immunoassays;Biosensors;2023-06-19
2. Fluorescence polarization immunoassay for the determination of diclofenac in wastewater;Analytical and Bioanalytical Chemistry;2020-11-25
3. Preface;Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences;2008-04-11