Selective inference in complex research

Author:

Benjamini Yoav1,Heller Ruth2,Yekutieli Daniel1

Affiliation:

1. Department of Statistics and Operations Research, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel

2. Faculty of Industrial Engineering and Management, Technicon–Israel Institute of Technology, Haifa, Israel

Abstract

We explain the problem of selective inference in complex research using a recently published study: a replicability study of the associations in order to reveal and establish risk loci for type 2 diabetes. The false discovery rate approach to such problems will be reviewed, and we further address two problems: (i) setting confidence intervals on the size of the risk at the selected locations and (ii) selecting the replicable results.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

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