Degradative transport of cationic amphiphilic drugs across phospholipid bilayers

Author:

Baciu Magdalena1,Sebai Sarra C1,Ces Oscar1,Mulet Xavier1,Clarke James A1,Shearman Gemma C1,Law Robert V1,Templer Richard H1,Plisson Christophe2,Parker Christine A2,Gee Antony2

Affiliation:

1. Department of Chemistry, Imperial College LondonSouth Kensington Campus, London SW7 2AZ, UK

2. PET Imaging Department, GlaxoSmithKline, ACCI, Addenbrookes HospitalCambridge CB2 2GG, UK

Abstract

Drug molecules must cross multiple cell membrane barriers to reach their site of action. We present evidence that one of the largest classes of pharmaceutical drug molecules, the cationic amphiphilic drugs (CADs), does so via a catalytic reaction that degrades the phospholipid fabric of the membrane. We find that CADs partition rapidly to the polar–apolar region of the membrane. At physiological pH, the protonated groups on the CAD catalyse the acid hydrolysis of the ester linkage present in the phospholipid chains, producing a fatty acid and a single-chain lipid. The single-chain lipids rapidly destabilize the membrane, causing membranous fragments to separate and diffuse away from the host. These membrane fragments carry the drug molecules with them. The entire process, from drug adsorption to drug release within micelles, occurs on a time-scale of seconds, compatible with in vivo drug diffusion rates. Given the rate at which the reaction occurs, it is probable that this process is a significant mechanism for drug transport.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

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