The pathology of multiple sclerosis and its evolution-Reference-Cited by-同舟云学术

The pathology of multiple sclerosis and its evolution

Published:1999-10-29 Issue:1390 Volume:354 Page:1635-1640
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. Lond. B

Author:

Lassmann H.¹

Affiliation:

1. Department of Meuroimmunology, Brain Research Institute, University of Vienna, SchwarZsPanierstrasse 17, A–1090 Vienna, Austria ()

Abstract

The pathology of multiple sclerosis (MS) was defined more than a century ago as a chronic inflammatory process which is associated with widespread primary demyelination and glial scarring. In this short review we discuss controversial issues on (i) the relationship between inflammation and demyelination, (ii) the various possible mechanisms of myelin destruction, and (iii) axonal involvement in this disease. We suggest that the disease process of MS is more complex that previously believed.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.1999.0508

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