The influence of the molecular basis of resistance on insecticide discovery

Abstract

This paper focuses on the process of invention and development of new insecticides and the impact of current research in resistance mechanisms on that process. The topic is introduced in the context of (i) the critical need to develop new insect–control agents to ensure a continued supply of high–quality food and fibre; (ii) how resistance development will continue to influence the potential to ensure the supply of these essentials; and (iii) why new insect–control technology is welcomed by growers. The main section of the paper describes a generic agrochemical invention process and discusses the impact that an understanding of the molecular basis of resistance will have on the various stages of this process, using specific examples to illustrate these points. By focusing on insecticide invention, this paper provides a context in which other information more specific to insecticide resistance from this issue can be understood.