Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Synergistic antibacterial activity between penicillenols and antibiotics against methicillin-resistant Staphylococcus aureus

Published:2018-05 Issue:5 Volume:5 Page:172466
ISSN:2054-5703
Container-title:Royal Society Open Science
language:en
Short-container-title:R. Soc. open sci.

Author:

Li Shuihong¹^ORCID,Mou Qianqian²,Xu Xinya³,Qi Shuhua³,Leung Polly H. M.²

Affiliation:

1. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, People's Republic of China

2. Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong 999077, People's Republic of China

3. Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China

Abstract

Penicillenol A2 (isolated from deep-sea fungus Penicillium biourgeianum DFFSCS023) has good antibacterial activity against methicillin-sensitive Staphylococcus aureus and in combination with beta -lactam antibiotics it could significantly decrease methicillin-resistant Staphylococcus aureus (MRSA) survival, which provides a novel treatment consideration for MRSA-caused infections.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Provience

China Postdoctoral Science Foundation

Hong Kong Scholars Program

Publisher

The Royal Society

Subject

Multidisciplinary

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.172466

Reference47 articles.