A vision and strategy for the virtual physiological human in 2010 and beyond-Reference-Cited by-同舟云学术

A vision and strategy for the virtual physiological human in 2010 and beyond

Published:2010-06-13 Issue:1920 Volume:368 Page:2595-2614
ISSN:1364-503X
Container-title:Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. A.

Author:

Hunter Peter¹²,Coveney Peter V.³,de Bono Bernard⁴,Diaz Vanessa⁵,Fenner John⁶,Frangi Alejandro F.⁷⁸⁹,Harris Peter¹⁰,Hose Rod⁶,Kohl Peter²,Lawford Pat⁶,McCormack Keith⁶,Mendes Miriam³,Omholt Stig¹¹,Quarteroni Alfio¹²¹³,Skår John¹⁴¹⁵,Tegner Jesper¹⁶,Randall Thomas S.¹⁷¹⁸,Tollis Ioannis¹⁹,Tsamardinos Ioannis¹⁹,van Beek Johannes H. G. M.²⁰,Viceconti Marco²¹

Affiliation:

1. Auckland Bioengineering Institute (ABI ), University of Auckland, Auckland, New Zealand

2. Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK

3. Centre for Computational Science, University College London, London, UK

4. European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK

5. Department of Mechanical Engineering, University College London, London, UK

6. Department Cardiovascular Science (Medical Physics Group ), Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

7. Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB ), Universitat Pompeu Fabra, Barcelona, Spain

8. Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN ), Barcelona, Spain

9. Institució Catalana de Recerca i Estudis Avançats (ICREA ), Barcelona, Spain

10. Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria, Australia

11. Centre for Integrative Genetics, Department of Animal Science, Norwegian University of Life Sciences, Norway

12. Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

13. Politecnico di Milano, Milan, Italy

14. Department Medicine, Unit for Computational Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

15. Department LIME, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

16. Department Medicine, Unit for Computational Medicine, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

17. EA IBISC University of Evry-Val d’Essonne, Evry, France

18. CNRS, Evry, France

19. Biomedical Informatics Laboratory (BMI ), Institute of Computer Science (ICS ), Foundation for Research and Technology (FORTH ) and Computer Science Department, University of Crete, Crete

20. Section Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands

21. Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna, Italy

Abstract

European funding under framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for nearly 2 years. The VPH network of excellence (NoE) is helping in the development of common standards, open-source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also helping to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by framework 6 strategy for a European physiome (STEP) project in 2006. It is now time to assess the accomplishments of the last 2 years and update the STEP vision for the VPH. We consider the biomedical science, healthcare and information and communications technology challenges facing the project and we propose the VPH Institute as a means of sustaining the vision of VPH beyond the time frame of the NoE.

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rsta.2010.0048

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