Abstract
During the past few years, the properties of a new enzyme, carbonic anhydrase, have been studied. This work is described in detail by Roughton (1934). Henriques (1928) had pointed out that the rate of evolution of CO
2
from the lungs was much more rapid than the evolution of CO
2
from a carbonic acid solution and concluded that: (
a
) there must be a catalyst present, or (
b
) the CO
2
was carried in some form other than bicarbonate. Brinkman, Margaria, and Roughton (1933) confirmed the view of Faurholt (1924) “ that in the range p
H
0-8 the equation
d
[CO
2
] /
dt
=
k
[H
2
CO
3
] -
k
' [CO
2
], corresponding to the mechanism 1 mol CO
2
+ 1 mol H
2
O ⇄ 1 mol H
2
CO
3
, holds good”. The values of
k
and
k
' given by Brinkman, Margaria, and Roughton are compared with those of Faurholt in Table I.
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