Abstract
I know of no higher honour which can come to an American laboratory than that which is implied in the invitation to a member of its staff to deliver a Croonian lecture before the Royal Society. The obligations which acceptance entails are heavy, particularly so in the present instance, inasmuch as the foundations of knowledge concerning the subject of which I am to speak have been laid by past fellows of this Society and its chief developments have been made by their successors. In accordance with the terms of the Council's invitation, what I shall have to say is based upon a series of connected studies which have been in progress in the Laboratory of Pharmacology of the University of Pennsylvania for more than twenty years and is the product of a succession of collaborations which it has been my privilege to enjoy.
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