Abstract
A high density lipoprotein (HDL
3
) from porcine plasma was studied by small-angle X-ray scattering techniques. Experiments were conducted in the presence of different concentrations of sucrose, which was employed to raise the electron density of the solvent. The form of the scattering curves, and the well-resolved secondary maxima indicated a high degree of symmetry and/or particle homogeneity. Wide-angle studies confirmed the presence of highly mobile liquid-like hydrocarbon chains. The data allowed a calculation of the spherically-averaged electron density distribution by Fourier inversion techniques. The range of experimentally determined scattering curves observed can be accounted for by a model for porcine HDL
3
structure with the following features: a particle of radius of gyration 5.5 nm. comprising a central low electron density (lipid) core (radius 4.2 nm) and an outer electron dense polar annulus (thickness 1.2 nm). By combining the X-ray data, and results from other studies, the probable location of the constituent molecular species can be suggested.
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