Abstract
Severe depletion of thymus-derived lymphocytes does not reduce, and may significantly increase, the resistance of mice to syngeneic tumours, although it grossly impairs their ability to reject allotransplants. Injection of killed
C. parvum
causes further inhibition of tumour growth in T-cell deprived mice to an extent comparable to that resulting from the same dose of
C.parvum
in normal mice. This appears to lend support to the hypothesis that the antitumour effect of
C. parvum
depends primarily on macrophage stimulation.
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