Renin induced proteinuria and the effects of adrenalectomy - I. Haemodynamic changes in relation to function

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Abstract

The degree of proteinuria induced by different pressor doses of pig renin, angiotensin II, adrenaline and noradrenaline in rats and the permissive role played by the adrenals in this respect, were investigated. No direct relationship could be established between elevation of blood pressure and pro­teinuria. A significant correlation was instead found between the increase in filtration fraction produced by these substances and their proteinuric effect. The absence of pro­teinuria in adrenalectomized rats was attributed to the severe impairment of renal blood supply caused by adrenalectomy. Corticosterone administration restored in four out of eight cases normal renal function and a normal proteinuric response to renin and angiotensin.

Publisher

The Royal Society

Subject

General Medicine

Reference43 articles.

1. Abbott E. C. Fraser R. Janes V. H. T. Parker R. A. & Peart W. S. 1967 The effect of sulphated mucopolysaccharide (R 01-837) on adrenal and kidney morphology and function in the rat. Unpublished data.

2. Addis T. 1931-2 Proteinuria and cylindruria. Proc. Calif. Acad. Med.. 43- 52.

3. Renin proteinuria in the rat. I. The relation between the proteinuria and the pressor effect of renin. J . exp;Addis T.;Med.,1949

4. Adrenalectomy and renin proteinuria in the rat. Fedn Proc. Fedn Am. Socs exp;Addis T.;Biol.,1949

5. Effect of Adrenalectomy on Spontaneous and Induced Proteinuria in the Rat.

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