Manipulation of the menstrual cycle

Abstract

The physiological mechanisms involved in controlling the ovarian and menstrual cycles are reviewed. With the exception of the combined contraceptive pill, widespread application of the existing methods of contraception in women is limited by their effects on the pattern of menstruation as well as by their effectiveness. Many attempts to manipulate the ovarian cycle for contraceptive purposes have unacceptable effects on the menstrual cycle. The possibility of producing amenorrhoea by altering the level of hypothalamic activity to mimic the state existing prepubertally and during lactation is discussed.