Abstract
This paper is a discussion of the value of protozoa as experimental organisms for the study of certain genetic problems. A number of examples of ‘cytoplasmic heredity’ are considered, some being based on DNA-containing particles, and others lacking such a material basis. Examples of the first type are the endosymbionts, such as kappa, and mitochondria; an example of the second type is the system of antigenic variation inParamecium. Brief mention is made of some studies on nucleo-cytoplasmic interactions inAmoeba, of the kinetoplast inTrypanosoma, and of some studies on the genetics of malaria parasites (Plasmodium bergheiand related species). As a final example of the value of protozoa in experimental research, reference is made to some behavioural mutants ofParameciumand the bearing of this work on some neurophysiological problems is indicated.
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