The lamina splendens of articular cartilage is an artefact of phase contrast microscopy

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Abstract

The so-called lamina splendens of articular cartilage is shown to be a characteristic of phase contrast microscopy; this technique provides no evidence for an anatomically distinct surface layer. Fresnel diffraction occurs at edges separating regions of different refractive indices. These diffraction effects, when viewed under phase contrast, lead to the appearance of a bright line along the edge.

Publisher

The Royal Society

Subject

General Medicine

Reference12 articles.

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5. Electron microscopy of articular cartilage in the young adult rabbit. Ann. rheum;Davies D. V.;Dis.,1962

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