Towards an advanced neurotechnological system: colorimetric sensing with a novel grism-based spectrometer, functionalized gold nanoparticles and a heterogeneous embedded system

Author:

Lachance Gabriel P.1,Boisselier Élodie2,Boukadoum Mounir3ORCID,Miled Amine1

Affiliation:

1. Department of Electrical and Computer Engineering, Université Laval, Québec Canada

2. Department of Ophthalmology and Otolaryngology-Head and Neck Surgery, Université Laval, Québec Canada

3. Department of Computer Science, Université du Québec À Montréal (UQÀM), Montréal, Québec, Canada

Abstract

Neurotransmitter sensing in the brain is crucial for the understanding of neuro-degenerative diseases. Most modern methods for the purpose rely on bulky instruments or are disruptive to the neurotransmitter medium. In this work, we describe and evaluate the design of a novel, compact and non-invasive instrument for neurotransmitter detection based on the colorimetric sensing method. The instrument includes a grism-based spectrometer that measures the wavelength shift of gold nanoparticles that are functionalized with aptamers to act as neurotransmitter-specific markers. It also includes microfluidic and electronic subsystems for sample preparation and control, and processing of the obtained signal. The instrument is tested with gold nanoparticles and its performance is compared to that of a commercial instrument, showing that the designed prototype matches the commercial instrument in performance while being much smaller, and it can surpass it with further improvements. This article is part of the theme issue ‘Advanced neurotechnologies: translating innovation for health and well-being’.

Funder

Natural Sciences and Engineering Research Council of Canada

RESMIQ, Quebec

Publisher

The Royal Society

Subject

General Physics and Astronomy,General Engineering,General Mathematics

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry;Sensors;2024-01-19

2. Preface to ‘Advanced neurotechnologies: translating innovation for health and well-being’;Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences;2022-06-06

3. Molecular sensing system based on multi-technologies architecture;Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics;2022-03-02

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