Abstract
Phosphate must be present in the urine to allow of the excretion of appreciable quantities of acid at a low hydrogen ion concentration, and Fitz, Alsberg and Henderson (1) showed that the urinary phosphate excretion is raised in acidosis. Some of the experiments here described were undertaken to determine the cause of this excretion. A study of the water, sodium and potassium excretion in acidosis was also made. The reaction of the body was made more acid either by breathing 6 to 7 per cent. CO
2
or by taking ammonium chloride ; more alkaline by over-breathing or sodium bicarbonate ingestion. Phosphates were estimated as described by Wigglesworth and Woodrow (2).
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