Abstract
The sensitivity of phage
T
7 to epoxides and freshly prepared solutions of di(2-chloroethyl) methylamine (
HN
2) was identical with that of
T
2.
T
7, however, proved considerably the more sensitive to ethylenimine and to aged solutions of
HN
2. It was considered that this was due to the cationic nature of these latter agents affecting the rate of penetration into the phage heads, and that the susceptibility of
T
2 and resistance of
T
7 to osmotic shock was a parallel phenomenon. Confirmation was afforded by the fact that a strain of
T
4 sensitive to osmotic shock behaved like
T
2, and a resistant strain of
T
4 like
T
7. These results, together with others previously reported, are believed to offer very strong evidence that inactivation of bacteriophage by alkylating agents derives from reaction with the deoxyribonucleic acid moiety, probably leading to a failure of the injection process.
Cited by
8 articles.
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