Abstract
Methionine sulphoximine (I,
R
═ CH
2
CH
2
CH(NH
2
)COOH,
R'
═ CH
3
) can be synthesized by the action of hydrazoic acid on methionine sulphoxide in the presence of concentrated sul-phuric acid as a catalyst and is shown to be identical with the toxic factor isolated from nitrogen trichloride-treated proteins. S-methylcysteine sulphoximine (I,
R
═ -CH
2
CH(NH
2
)COOH,
R'
═ CH
3
) and dimethyl. sulphoximine (I,
R
,
R'
═ CH
3
) are prepared by a similar method from the corresponding sulphoxides; in rabbits, S-methylcysteine sulphoximine does not produce the toxic symptoms obtained with methionine sulphoximine. Possible mechanisms are discussed for the reaction between hydrazoic acid and a sulphoxide.
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5. jhillman J. H. & Harting W. F. 1948
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