Walking humans and running mice: perception and neural encoding of optic flow during self-motion

Abstract

Locomotion produces full-field optic flow that often dominates the visual motion inputs to an observer. The perception of optic flow is in turn important for animals to guide their heading and interact with moving objects. Understanding how locomotion influences optic flow processing and perception is therefore essential to understand how animals successfully interact with their environment. Here, we review research investigating how perception and neural encoding of optic flow are altered during self-motion, focusing on locomotion. Self-motion has been found to influence estimation and sensitivity for optic flow speed and direction. Nonvisual self-motion signals also increase compensation for self-driven optic flow when parsing the visual motion of moving objects. The integration of visual and nonvisual self-motion signals largely follows principles of Bayesian inference and can improve the precision and accuracy of self-motion perception. The calibration of visual and nonvisual self-motion signals is dynamic, reflecting the changing visuomotor contingencies across different environmental contexts. Throughout this review, we consider experimental research using humans, non-human primates and mice. We highlight experimental challenges and opportunities afforded by each of these species and draw parallels between experimental findings. These findings reveal a profound influence of locomotion on optic flow processing and perception across species. This article is part of a discussion meeting issue ‘New approaches to 3D vision’.