Mathematical constraints onFST: multiallelic markers in arbitrarily many populations

Author:

Alcala Nicolas1ORCID,Rosenberg Noah A.2ORCID

Affiliation:

1. Rare Cancers Genomics Team (RCG), Genetic Epidemiology Branch (GEM), International Agency for Research on Cancer/World Health Organization, Lyon 69008, France

2. Department of Biology, Stanford University, Stanford, CA 94305-5020, USA

Abstract

Interpretations of values of theFSTmeasure of genetic differentiation rely on an understanding of its mathematical constraints. Previously, it has been shown thatFSTvalues computed from a biallelic locus in a set of multiple populations andFSTvalues computed from a multiallelic locus in a pair of populations are mathematically constrained as a function of the frequency of the allele that is most frequent across populations. We generalize from these cases to report here the mathematical constraint onFSTgiven the frequencyMof the most frequent allele at amultialleliclocus in a set ofmultiplepopulations. Using coalescent simulations of an island model of migration with an infinitely-many-alleles mutation model, we argue that the joint distribution ofFSTandMhelps in disentangling the separate influences of mutation and migration onFST. Finally, we show that our results explain a puzzling pattern of microsatellite differentiation: the lowerFSTin an interspecific comparison between humans and chimpanzees than in the comparison of chimpanzee populations. We discuss the implications of our results for the use ofFST.This article is part of the theme issue ‘Celebrating 50 years since Lewontin's apportionment of human diversity’.

Funder

National Human Genome Research Institute

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3