The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions

Author:

Jansson John-Olov1ORCID,Anesten Frederik1,Hägg Daniel1,Zlatkovic Jovana1,Dickson Suzanne L.1,Jansson Per-Anders1,Schéle Erik1,Bellman Jakob1,Ohlsson Claes1

Affiliation:

1. Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, S-41390 Göteborg, Västra Götaland, Sweden

Abstract

Body weight is tightly regulated when outside the normal range. It has been proposed that there are individual-specific lower and upper intervention points for when the homeostatic regulation of body weight is initiated. The nature of the homeostatic mechanisms regulating body weight at the lower and upper ends of the body weight spectrum might differ. Previous studies demonstrate that leptin is the main regulator of body weight at the lower end of the body weight spectrum. We have proposed that land-living animals use gravity to regulate their body weight. We named this homeostatic system the gravitostat and proposed that there are two components of the gravitostat. First, an obvious mechanism involves increased energy consumption in relation to body weight when working against gravity on land. In addition, we propose that there exists a component, involving sensing of the body weight by osteocytes in the weight-bearing bones, resulting in a feedback regulation of energy metabolism and body weight. The gravity-dependent homeostatic regulation is mainly active in obese mice. We, herein, propose the dual hypothesis of body weight regulation , including gravity-dependent actions (= gravitostat) at the upper end and leptin-dependent actions at the lower end of the body weight spectrum. This article is part of a discussion meeting issue ‘Causes of obesity: theories, conjectures and evidence (Part II)’.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference37 articles.

1. The evolution of body fatness: trading off disease and predation risk

2. Obesity: an evolutionary context

3. Bernard C. 1865 Introduction à l'étude de la médecine expérimentale [Introduction to the study of experimental medicine]. Paris, France: Flammarion. [In French.]

4. THE WISDOM OF THE BODY

5. The role of depot fat in the hypothalamic control of food intake in the rat

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3