Abstract
Although
in vivo
31
P NMR permits unique measurements of the body’s stores of high energy phosphate metabolites, their low concentrations place critical limits and demands on spatial resolution, localization techniques, and reproducibility. We argue that optimum reliability and reproducibility of
in vivo
measurements of metabolite ratios and concentrations is best achieved by preselecting the minimal requirements for spatial localization suited to, and varying with, the particular organ and disease type. Strategies for measuring metabolite ratios and concentrations in the human heart and brain are discussed and demonstrated in the context of the expeditious choice of operating parameters, including localized volume size, localization technique, NMR coils, radiofrequency-field uniformity, patient positioning, and corrections for spectral distortion caused by NMR relaxation, to optimize the return of useful metabolic information in practical clinical research exams of about an hour duration.
Subject
Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献