An efficient synthesis of furan-3(2 H )-imine scaffold from alkynones

Abstract

A novel efficient method to generate spiro furan-3(2 H )-imine derivatives is established by the reaction between the α , β -unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2 H )-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).