Seasonal Factors of Adaptation of Water-Mineral Chronoperiodical System in Healthy Individuals and Patients With Syndrome of Vegetative Dystonia

Abstract

Objective: The aim of this study was to examine the peculiarities of various components of water-mineral chronoperiodical system under the action of seasonal factors in practically healthy individuals and in patients with the syndrome of vegetative dystonia (SVD). Methods: Forty practically healthy individuals and 38 ambulatory patients with SVD were investigated. Practically healthy subjects and patients with SVD were on identical regimen (sleep, wake, and diet). Four-hour urine specimens were collected over a period of 72–120 hours, with duration of 4–5 days. Each sample of urine was analyzed for electrolytes and some microelements. Temporal organization (biological and weather factors) parameters have been measured by nonlinear least squares method for the rhythms with sinusoidal structure and dispersion analysis for the rhythms with non-sinusoidal organization. Parameters of weather factors were received from the hydrometeorological service of Yerevan, Armenia.Results: Healthy subjects were characterized with the circadian structure of macro and microelements chronoperiodical system. Acrophases of the biorhythms were individual, and were outstripping the acrophases of the weather indices’ oscillations.Conclusion: Chronostructure of macro- and microelement homeostasis in patients with SVD were characterized with infradian oscillations. For patients with SVD, significant correlation between rhythms of electrolytes and trace elements and oscillations of weather factors was different in comparison with the data for healthy subjects. In patients with SVD, acrophases of chronoperiodical system of electrolytes and microelements frequently were concurrent relative to the acrophases of fluctuations of the weather factors.