Effects of Sizes and Anisotropy Constants of Magnetic Nanoparticles on Hyperthermia Temperature Increase with Time

Abstract

Cancer cells can be killed by magnetic-nanoparticles-induced hysteresis heat under an external alternating magnetic field. However, the hysteresis heat-induced temperature must be precisely controlled to prevent damages to the ambient normal tissue from cancer cells. Therefore, this study employs a heat model to analyze the variation of temperature with time in magnetic nanoparticles within cancer. Results show that the temperature increase with time predicted from this study is consistent with the available experimental data. The effect of anisotropy constant on temperature rise with time is presented. The anisotropy constant makes the behaviours of temperature variation significantly different.