Extracts from lichen <i>Lobaria retigera</i> decrease the stemness potential of colorectal cancer cells-Reference-Cited by-同舟云学术

Extracts from lichen Lobaria retigera decrease the stemness potential of colorectal cancer cells

Published:2022-02-01 Issue:2 Volume:12 Page:234-240
ISSN:2158-5849
Container-title:Materials Express
language:en
Short-container-title:mat express

Author:

Zhou Rui¹,Nguyen Thanh Thi¹,Kim Kyung Keun²,Hur Jae-Seoun³,Kim Hangun¹

Affiliation:

1. College of Pharmacy, Sunchon National University, Sunchon, Jeonnam, 57922, Korea

2. Department of Pharmacology, Chonnam National University Medical School, Gwangju, 61469, Korea

3. Korean Lichen Research Institute, Sunchon National University, Sunchon, Jeonnam, 57922, Korea

Abstract

Lichens are symbiotic organisms with the potential to be used in the pharmaceutical industry. To identify novel lichen extracts that inhibit the stemness potential of colorectal cancer cells, we tested acetone extracts of Lobaria retigera collected in Vietnam. Crude acetone extracts of L. retigera decreased spheroid formation in CSC221, DLD1, and HT29 cells. In addition, mRNA levels of genes encoding cancer stem markers aldehyde dehydrogenase-1, CD44, CD133, Lgr5, and Musashi-1 were significantly downregulated in a dose-dependent manner after treatment with L. retigera extract. Moreover, L. retigera extract decreased the transcriptional activities of Gli and the Notch-related Hes1 promoter in reporter assays. Together, these results demonstrate that L. retigera extract is a potent inhibitor of colorectal cancer cell stemness.

Publisher

American Scientific Publishers

Subject

General Materials Science

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