Synthesis of Au NPs/Quince nanoparticles mediated by Quince extract for the treatment of human cervical cancer: Introducing a novel chemotherapeutic supplement

Abstract

In this study, we have prepared mono-dispersed gold nanoparticles using the aqueous extract of Quince. The effective phytocompounds in the extract carried out the function as both reducing and stabilizing agents in the synthesis of Au NPs. The reduction of Au3+ ions into Au0 NPs was indicated by a visual transform in color from pale yellow to deep red. UV-Vis studies revealed the characteristic surface plasmon resonance band appeared at around 545 nm. FT-IR, TEM, SEM, EDX, XRD, and UV/Vis analytical methods were employed to characterize the Au NPs/Quince nanocomposite. TEM study revealed globular shaped NPs having particle size around 20–30 nm. Towards its biological implication, MTT method was followed in order to survey the cytotoxicity and inhibition of human cervical cancer against Hela, SiHa, and CCI-PI 19 cell lines and the corresponding IC50 values were evaluated as 465, 712, and 785 μg/mL respectively. The % cell viabilities diminished dose-dependently over the bio-nanomaterial. To survey the antioxidant properties of Au NPs/Quince, DPPH assay was used and here the related IC50 value was determined as 72 μg/mL.