Neuroprotection of silver nanowires (Ag NWs) with different sizes in stroke

Abstract

In this report, silver nanowires (NWs) with different sizes have been obtained by using the poly process synthesis method. As-synthesized samples 1, 2, and 3 with high purity and different sizes have been obtained by changing the amount and kind of inorganic agent in the synthesis procedure. Three samples have been characterized by the scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD). The SEM images of Ag NW 1 (74 nm in diameter, 20–30 μm in length), Ag NW 2 with (60 nm in diameter, 30–40 μm in length), and Ag NWs 3 with (46 nm in diameter, 30–40 μm in length) are obtained. The PXRD results for Ag NWs 1–3 show four typical diffraction peaks at 38.2°, 44.5°, 64.5°, and 77.4°, matching the face-centered cubic lattice for Ag substance and confirming the purity of the Ag NWs sample. In addition, the relative expression of the PTEN and mTOR was determined with real-time RT-PCR at the mRNA level. The content of inflammatory cytokines during stoke was measured with indicated ELISA assay.