Preparation, characterization and application of docetaxel-loaded methoxy polyethylene glycol-octacosanol micelles for breast cancer therapy

Abstract

Objective: To prepare docetaxel (DOC)-loaded methoxy polyethylene glycol-octacosanol (MPEG2K-Oct) micelles and evaluate the in vitro and in vivo antitumor activity. Methods: DOC/MPEG-Oct was prepared using the thin-film hydration method. The physicochemical property including size, zeta potential and drug release behavior were studies. The in vitro cytotoxicity and the in vivo antitumor activity were evaluated. Results: The prepared DOC/MPEG-Oct micelles had a small size, as well as high drug loading capacity and encapsulation efficiency. These micelles also performed a sustained and controllable in vitro drug release. Besides, they showed a good inhibiting effect of tumor growth both in vitro and in vivo. Conclusion: DOC/MPEG-Oct nanomicelles might be considered as a safe and efficient drug delivery system for DOC.