Voltammetric Determination of Phenylephrine Hydrochloride at Poly (Diphenylamine Sulfonic Acid) Electrode

Abstract

The electrochemical behaviour was studied, and the determination method of phenylephrine hydrochloride (PHE) at wide pH range at poly (Diphenylamine Sulfonic Acid, DPSA), using cyclic voltammetric (CV), differential pulse voltammetric (DPV) techniques. Optimum conditions and optimization of parameters for analytical applications were obtained by DPV technique, this technique was selected for the determination. Using optimized DPV technique, the current was linear within a concentration range between 10–100 nM in pH 6.5 phosphate buffer (PBS). Furthermore, poly (DPSA) electrodes were successfully applied to the determination of PHE in spiked urine and pharmaceutical preparations, rapid and low-cost method. The repeatability, accuracy and precision of the developed technique were checked.