Correlation Analysis of Immune Cell Infiltration in Recurrent Endometrial Carcinoma

Author:

Wang Wenzhi1,Liu Xiaoying1,Zheng Lei2

Affiliation:

1. Department of Gynaecology, Shaanxi Provincial People’s Hospital, Xi’an, 710000, China

2. College of Pharmacy, Xi’an Medical University, Xi’an, 710021, China

Abstract

Numerous studies have established a close relationship between tumor progression, prognosis, and the infiltration of immune cells in the tumor microenvironment. This study aimed to investigate the differences in infiltrating immune cells between recurrent endometrial cancer and non-recurrent endometrial cancer. Firstly, gene expression data of endometrial cancer were obtained from the GEO database. Differential gene analysis using Geo2R identified significant gene expression differences, and KEGG and GO analyses were conducted on the qualified differential genes. Subsequently, CIBERSORT was employed to analyze the infiltration of 22 immune cell types in the tumor microenvironment, identifying differential immune cells. The results revealed significant differences in gene expression between recurrent and non-recurrent endometrial carcinoma. Interestingly, CIBERSORT analysis demonstrated a significant increase in monocyte infiltration in recurrent endometrial cancer compared to non-recurrent cases. Monocyte infiltration was found to play a crucial role in the progression of endometrial cancer recurrence. These findings provide valuable insights for clinicians to develop personalized treatment strategies for patients with recurrent endometrial cancer.

Publisher

American Scientific Publishers

Subject

Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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