Co-Delivery of Curcumin and Resveratrol via a Hydrogel/Nanoparticle System Modulate NF-kB Inflammatory Signalling Pathway in Rat Model of Traumatic Spinal Cord Injury

Abstract

In this research, a nanocomposite delivery system was developed for the delivery of curcumin and resveratrol to treat spinal cord injury in rat model. The nanoparticles were prepared using the ionotropic gelation method and then dispersed in a calcium alginate hydrogel. The delivery system was characterized in vitro and its healing potential was evaluated in a rat model of spinal cord injury. Study showed that the nanocomposite system was not toxic against PC-12 cells and showed a sustained release profile for both drugs. In vivo study showed that co-administration of curcumin and resveratrol had significantly higher healing activity compared with the animals treated with other groups. In addition, the delivery system downregulated the expression profile of NF-kB and TNF-a genes.