Catha Edulis Extract Loaded Nanofibrous Neural Channels Augment Sciatic Nerve Injury Repair Trough Upregulation of BDNF and NGF Genes

Abstract

The study investigated the impact of regular treadmill exercise and catha edulis extract-loaded nanofibrous scaffolds on rats with sciatic nerve injury. The findings indicated that PC-12 cells survived on the membranes and exhibited greater metabolic activity on the catha edulis extract-loaded nanofibrous membranes. Furthermore, the combined approach improved sciatic nerve healing, as confirmed by histopathological examinations and functional recovery in vivo. Additionally, gene expression studies revealed an increase in BDNF and NGF genes due to this approach.