Edaravone-Delivering PVA-Chitosan Nanofibrous Wound Dressings Promote Diabetic Wound Healing Through Modulation of Oxidative Stress and Inflammation

Abstract

In the current study, edaravone was loaded into electrospun PVA/chitosan wound dressings to develop a potential wound care material for diabetic wounds. Different in vitro studies were performed to characterize the dressings. In vivo study was carried out in a rat model of diabetic wound healing. Study showed that the nanofibrous membranes prevented bacterial penetration and showed no toxicity toward skin fibroblast cells. In vivo study showed that edaravone-loaded wound dressings had the highest rate of wound closure and formation of new epithelium compared with other groups. Gene expression study showed that TNF-a and GP-x genes tissue expression was significantly downregulated in the rats treated with edaravone-delivering wound dressings, implying that these dressings have modulated oxidative stress and inflammation in diabetic wounds.