Development of a Machine Learning-Assisted Model for the Early Detection of Severe COVID-19 Cases Combining Blood Test and Quantitative Computed Tomography Parameters

Author:

Huang Xiaoqi1,Shi Ke2,Zhou Jie3,Liang Yudong4,Liu Yaliang5,Zhang Jinpin6,Guo Youmin6,Jin Chenwang6

Affiliation:

1. Department of Radiology, The Affiliated Hospital of Yan’an University, Yan’an, 716000, China

2. Department of Radiology, Ankang People’s Hospital, Ankang, 725000, China

3. Department of Radiology, Xi’an Chest Hospital, Xi’an, 710000, China

4. Department of CT&MR Imaging Diagnostics, Weinan Central Hospital, Weinan, 714000, China

5. Department of Radiology, Hanzhong Central Hospital, Hanzhong, 723000, China

6. Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710000, Shaanxi, China

Abstract

<sec> <title>Purpose:</title> This study aimed to identify severe Coronavirus Disease 2019 (COVID-19) cases combining blood test results and imaging parameters based on a machine learning classifier at the initial admission. </sec> <sec> <title>Materials and methods:</title> Ninety-five non-severe and 22 severe laboratory-confirmed COVID-19 cases treated between January 23, 2020 and March 25, 2020 were examined in this retrospective trial. Blood test results and chest computed tomography (CT) images were obtained at the initial admission. The lesions on CT images were segmented using an artificial intelligent (AI) tool. Then, quantitative CT (QCT) parameters, including the volume, percentage, ground glass opacity (GGO) percentage and heterogeneity of the lesions were calculated. Correlations of blood test results and QCT parameters were analyzed by the Pearson test first. Then, discriminative features for detecting severe cases were selected by both the independent samples t test and least absolute shrinkage and selection operator (LASSO) regression. Next, support vector machine (SVM), Gaussian naïve Bayes (GNB), Knearest neighbor (KNN), decision tree (DT), random forest (RF) and multi-layer perceptron-neural net (MLP-NN) algorithms were used as classifiers, and their accuracies were assessed by 10-fold-cross-validation. </sec> <sec> <title>Results:</title> Blood test indexes and CT parameters were moderately to medially correlated. Of all selected features, lesion percentage contributed mostly to the classification of the two groups, followed by lesion volume, patient age, lymphocyte count, neutrophil count, GGO percentage and tumor heterogeneity. RF-assisted identification had the highest accuracy of 91.38%, followed by GNB (87.83%), KNN (87.93%), SVM (86.21%), MLP-NN (85.34%) and DT (84.48%). </sec> <sec> <title>Conclusions:</title> The RF-assisted model combining blood test and QCT parameters is helpful in the identification of severe COVID-19 cases. </sec>

Publisher

American Scientific Publishers

Subject

Health Informatics,Radiology, Nuclear Medicine and imaging

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3