T1 Mapping for Noninvasively Detecting Diffuse Fibrosis in Severe Aortic Stenosis-Reference-Cited by-同舟云学术

T1 Mapping for Noninvasively Detecting Diffuse Fibrosis in Severe Aortic Stenosis

Published:2020-07-01 Issue:7 Volume:10 Page:1534-1539
ISSN:2156-7018
Container-title:Journal of Medical Imaging and Health Informatics
language:en
Short-container-title:j med imaging hlth inform

Author:

Xie Jiajun¹,Jian Xuhua²,Lu Qiyang³,Meng Jinxiu⁴,Juan Yu-Hsiang⁵,Ou Qiong⁶,Yu Zhuliang⁷,Yang Xiangtai⁸,Liu Hui³

Affiliation:

1. Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China

2. Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510030, China

3. Department of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510641, China

4. Medical Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510030, China

5. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou and Healthy Aging Research Center, Chang Gung University, Taoyuan, 10699, Taiwan

6. Sleep Center, Department of Respiratory and Critical Care Medicine, Guangdong Institute of Geriatrics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong, 510030, China

7. School of Automation Science and Engineering, South China University of Technology, Guangzhou, Guangdong, 510030, China

8. Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510030, China

Abstract

Purpose: To evaluate myocardial diffuse fibrosis in severe aortic stenosis (SAS) with cardiac magnetic resonance imaging (MRI) T1 mapping technique. Methods: Twenty-seven SAS patients and 15 controls were enrolled and performed cardiac MRI. Left ventricular (LV) structure, function and T1-derived parameters were measured to compare between SAS group and the controls. Correlation between T1-derived parameters and the extent of histologic fibrosis was performed in 15 patients who underwent aortic valve replacement surgery and myocardial biopsy. Results: The SAS group had LV remodeling with ventricular dilatation, hypertrophy, and contractile dysfunction. The native T1 (1336.2±62.5 ms vs. 1277.6±40.7 ms, p = 0.002) and extracellular volume fraction (ECV%) (26.7±2.2% vs. 24.9±2.2%, p = 0.018) were elevated in the SAS in comparison to the controls. Only ECV and λ correlated with the extent of fibrosis as measured by histology. Conclusion: Cardiac MRI with T1 mapping provides a noninvasive approach to evaluate LV myocardial diffuse fibrosis in SAS.

Publisher

American Scientific Publishers

Subject

Health Informatics,Radiology Nuclear Medicine and imaging