Statistical Analysis of Homocysteine and Folate on the Regulation of Blood Pressure
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Published:2019-10-01
Issue:8
Volume:9
Page:1563-1567
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ISSN:2156-7018
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Container-title:Journal of Medical Imaging and Health Informatics
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language:en
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Short-container-title:j med imaging hlth inform
Author:
Huang Zhigang,Shi Lin,Sun Ningling
Abstract
Objective: To investigate and statistically analyze homocysteine and folate on the regulation of blood pressure in spontaneously hypertensive rats (SHR), and explore whether the effect is related to angiotensin II type L receptor (AT1R) with bioinformatics. Methods:
Eighteen SHRs were randomly divided into three groups: control group, methionine (Met) group and folate group (Met plus folate). Heart rate and blood pressure were monitored at different times. Serum Hcy levels were measured by ELISA kits. The expression of AT1R was detected by
protein immunoblot. Results: Statistical analysis results indicated that mean arterial pressure (MAP) of the Met group at 4 and 6 weeks showed an increasing trend compared with the control group. And the Folate group at 4 weeks presented a decreasing trend compared with the Met group.
The MAP of the other groups presented that great variation and no obvious trend. Serum Hcy levels were significantly increased in Met group, but decreased in folate group. AT1R protein were significantly decreased in Met and folate group. Conclusion: Hcy increased the MAP
to a certain extent, and folic acid had a weak response to intervention to the effect. AT1R protein in renal tissue may not be a major effector in the pathway of elevated blood pressure.
Publisher
American Scientific Publishers
Subject
Health Informatics,Radiology Nuclear Medicine and imaging
Cited by
1 articles.
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