The Remarkable Efficiency of Melanin Reduction by Using Functional Organelle, Lysosomes

Abstract

Lysosomes have reported that lysosomal intensity increased depending by aging. Lysosome and melanosome have some relations because melanosome has same producing pathway with lysosomes. Therefore we evaluated lysosomal intensity with efficiency of melanin reduction. We found that lysosomes can decrease the amount of melanin by their specialized functions in vivo. The melanin quantity compared in melanocytes after exposure to ultraviolet (UV) radiation and α-melanocyte stimulation hormone (α-MSH) for evaluation expression level on different influence. Additionally, we compared the ability to reduce the amount of melanin after exposure to oxidative stress. Lastly we treated lysosomes isolated from HeLa cells to reduce melanin in melanocytes. 2% lysosomes were effective in reducing the amount of melanin in cells. Therefore, we conclude that lysosomes are a useful bio agent for decreasing the amount of melanin.