Effects of Tanshinone on Hemodynamics and Expression of NF- B and Myeloperoxidase in Rats with Spinal Cord Ischemia-Reperfusion Injury

Author:

Wang Rubiao,Xie Wenjun,Rao Hongrong,Tan Yujian,Liao Rongkun,Jiang Yingmei,Zhang Hongbin

Abstract

Spinal cord ischemia-reperfusion injury (SCII) can cause spinal nerve injury and loss of function. Tanshinone IIA has antioxidant activity. However, the effect of tanshinone on SCII rats remains unclear. SD rats were randomly divided sham operation group (sham group), SCII group and tanshinone group. Heart rhythm (HR), mean blood pressure (MAP), and myocardial oxygen consumption index (RPP) hemodynamic parameters were analyzed. Rat neurological function scores were performed by the Tarlov method. The glutamate detection kit was used to detect the content of glutamate, superoxide dismutase (SOD) and myeloperoxidase (MPO). NF-κ B protein expression was assessed by Western blot. The expressions of tumor necrosis factor-α (TNF-α) and interleukin6 (IL-6) were analyzed by ELISA. In SCII group, HR, MAP, RPP, and neurological function score as well as SOD activity were significantly decreased with increased MPO, glutamate, TNF-α and IL-6 secretion as well as elevated NF-κ B expression compared with sham group (P < 0 05). After tanshinone treatment, HR, MAP, RPP, and neurological function score as well as SOD activity were all significantly increased along with decreased MPO, glutamate, TNF-α and IL-6 secretion, as well as reduced NF- κB expression compared with SCII group (P < 0 05). Tanshinone can improve the oxidative stress, reduce the secretion of inflammatory factors, and improve hemodynamics which is possibly through regulating NF-κ B expression.

Publisher

American Scientific Publishers

Subject

Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3