A Novel Vaccaria Semen Carbonisatum Carbon Nanocomposites and Their Protective Effects on Alcohol-Induced Liver Injury in Mice

Abstract

Objective: To discover the efficacy of Vaccariae Semen Carbonisatum nano-components (VSC-NCs) on alcoholic liver injury in mice. Methods: VSC was calcined at high temperature in a muffle furnace, and VSC-NCs were extracted and isolated. Mouse model of alcoholic liver injury was used and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bile acid (TBA), oxidative stress and histopathological assessments were done. Results: Characterization and analysis showed that VSC-NCs were spherical, with a particle size distribution of 1.0 to 5.5 nm. The results of animal experiments showed that VSC-NCs could significantly reduce the content of ALT, AST, TBA and ALP in mice with alcohol-induced liver injury, and at the same time significantly increase the level of SOD and reduce the level of malondialdehyde. These results indicated that VSC-NCs could improve the scavenging of reactive oxygen species (ROS) in the body. The ability to reduce the production of lipid peroxides, so as to achieve hepatoprotective effect. Conclusion: VSC-NCs were prepared for the first time, and was confirmed that it has a significant protective effect on liver injury caused by alcohol. In addition, VSC-NCs can be used as a potential drug for the treatment of alcohol-induced liver injury.